Regional: 2025 Time Is Brain: Advances in Stroke Care (20th Annual): Cancer-Associated Ischemic Stroke (1:30 PM)

Cancer-Associated Ischemic Stroke (1:30 PM)

Dylan Ryan, MD
Dylan Ryan is an Assistant Professor of Neurology at Duke University Hospital in the division of stroke and vascular neurology. He obtained his MD at the University of Kentucky and completed residency in neurology as well as a vascular neurology fellowship at Duke University. His primary research interest is in stroke in patients with active malignancy. He is also actively involved in education and currently serves on the StrokeNet Training and Education Core.

Articles

Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke: A Post Hoc Analysis of the ARCADIA Randomized Clinical Trial
Navi BB, Zhang C, Miller B, Cushman M, Kasner SE, Elkind MSV, Tirschwell DL, Longstreth WT Jr, Kronmal RA, Beyeler M, Elm J, Zweifler RM, Tarsia J, Cereda CW, Bianco G, Costamagna G, Michel P, Broderick JP, Gladstone DJ, Kamel H, Streib C. Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke: A Post Hoc Analysis of the ARCADIA Randomized Clinical Trial. JAMA Neurol. 2024 Sep 1;81(9):958-965. doi: 10.1001/jamaneurol.2024.2404. PMID: 39133474; PMCID: PMC11320331.
Arterial and venous thrombosis in cancer patients
Blann AD, Dunmore S. Arterial and venous thrombosis in cancer patients. Cardiol Res Pract. 2011 Mar 3;2011:394740. doi: 10.4061/2011/394740. PMID: 21403876; PMCID: PMC3051163.
Association between incident cancer and subsequent stroke
Navi BB, Reiner AS, Kamel H, Iadecola C, Elkind MS, Panageas KS, DeAngelis LM. Association between incident cancer and subsequent stroke. Ann Neurol. 2015 Feb;77(2):291-300. doi: 10.1002/ana.24325. Epub 2015 Jan 7. PMID: 25472885; PMCID: PMC4315703.
Cancer-associated pathways and biomarkers of venous thrombosis
Hisada Y, Mackman N. Cancer-associated pathways and biomarkers of venous thrombosis. Blood. 2017 Sep 28;130(13):1499-1506. doi: 10.1182/blood-2017-03-743211. Epub 2017 Aug 14. PMID: 28807983; PMCID: PMC5620413.
Cancer and Embolic Stroke of Undetermined Source
Navi BB, Kasner SE, Elkind MSV, Cushman M, Bang OY, DeAngelis LM. Cancer and Embolic Stroke of Undetermined Source. Stroke. 2021 Mar;52(3):1121-1130. doi: 10.1161/STROKEAHA.120.032002. Epub 2021 Jan 28. PMID: 33504187; PMCID: PMC7902455.
Cancer Cell-Derived Extracellular Vesicles Are Associated with Coagulopathy Causing Ischemic Stroke via Tissue Factor-Independent Way: The OASIS-CANCER Study
Bang OY, Chung JW, Lee MJ, Kim SJ, Cho YH, Kim GM, Chung CS, Lee KH, Ahn MJ, Moon GJ. Cancer Cell-Derived Extracellular Vesicles Are Associated with Coagulopathy Causing Ischemic Stroke via Tissue Factor-Independent Way: The OASIS-CANCER Study. PLoS One. 2016 Jul 18;11(7):e0159170. doi: 10.1371/journal.pone.0159170. PMID: 27427978; PMCID: PMC4948859.
Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients
Mauracher LM, Posch F, Martinod K, Grilz E, Däullary T, Hell L, Brostjan C, Zielinski C, Ay C, Wagner DD, Pabinger I, Thaler J. Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients. J Thromb Haemost. 2018 Mar;16(3):508-518. doi: 10.1111/jth.13951. Epub 2018 Feb 7. PMID: 29325226; PMCID: PMC6294121.
Coagulation Factor Expression and Composition of Arterial Thrombi in Cancer-Associated Stroke
Yoo J, Kwon I, Kim S, Kim HM, Kim YD, Nam HS, Heo JH. Coagulation Factor Expression and Composition of Arterial Thrombi in Cancer-Associated Stroke. Stroke. 2023 Dec;54(12):2981-2989. doi: 10.1161/STROKEAHA.123.044910. Epub 2023 Oct 27. PMID: 37886852.
Cultured human endothelial cells generate tissue factor in response to endotoxin
Colucci M, Balconi G, Lorenzet R, Pietra A, Locati D, Donati MB, Semeraro N. Cultured human endothelial cells generate tissue factor in response to endotoxin. J Clin Invest. 1983 Jun;71(6):1893-6. doi: 10.1172/jci110945. PMID: 6345590; PMCID: PMC370395.
Diagnostic yield of echocardiography in cancer patients with ischemic stroke
Merkler AE, Navi BB, Singer S, Cheng NT, Stone JB, Kamel H, Iadecola C, Elkind MS, DeAngelis LM. Diagnostic yield of echocardiography in cancer patients with ischemic stroke. J Neurooncol. 2015 May;123(1):115-21. doi: 10.1007/s11060-015-1768-3. Epub 2015 Apr 8. PMID: 25851114; PMCID: PMC4441574.
Efficacy and safety of intravenous thrombolysis for acute ischemic stroke in cancer patients: a systemic review and meta-analysis
Huang S, Lu X, Tang LV, Hu Y. Efficacy and safety of intravenous thrombolysis for acute ischemic stroke in cancer patients: a systemic review and meta-analysis. Am J Transl Res. 2020 Aug 15;12(8):4795-4806. PMID: 32913551; PMCID: PMC7476124.
Endovascular Treatment in Patients With Acute Ischemic Stroke and Comorbid Cancer: Analysis of the Italian Registry of Endovascular Treatment in Acute Stroke
Letteri, Federica, et al. "Endovascular treatment in patients with acute ischemic stroke and comorbid cancer: analysis of the Italian Registry of Endovascular Treatment in Acute Stroke." Stroke: Vascular and Interventional Neurology 3.3 (2023): e000423.
An enzyme-linked immunosorbent assay for cancer procoagulant and its potential as a new tumor marker (Abstract)
Gordon SG, Cross BA. An enzyme-linked immunosorbent assay for cancer procoagulant and its potential as a new tumor marker. Cancer Res. 1990 Oct 1;50(19):6229-34. PMID: 2169340.
Epidemiology, Pathophysiology, and Management of Cancer-Associated Ischemic Stroke
Ryan D, Bou Dargham T, Ikramuddin S, Shekhar S, Sengupta S, Feng W. Epidemiology, Pathophysiology, and Management of Cancer-Associated Ischemic Stroke. Cancers (Basel). 2024 Nov 29;16(23):4016. doi: 10.3390/cancers16234016. PMID: 39682202; PMCID: PMC11640599.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4. PMID: 38572751.
Guidelines for Adult Stroke Rehabilitation and Recovery: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
Winstein CJ, Stein J, Arena R, Bates B, Cherney LR, Cramer SC, Deruyter F, Eng JJ, Fisher B, Harvey RL, Lang CE, MacKay-Lyons M, Ottenbacher KJ, Pugh S, Reeves MJ, Richards LG, Stiers W, Zorowitz RD; American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Quality of Care and Outcomes Research. Guidelines for Adult Stroke Rehabilitation and Recovery: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2016 Jun;47(6):e98-e169. doi: 10.1161/STR.0000000000000098. Epub 2016 May 4. Erratum in: Stroke. 2017 Feb;48(2):e78. doi: 10.1161/STR.0000000000000120. Erratum in: Stroke. 2017 Dec;48(12):e369. doi: 10.1161/STR.0000000000000156. PMID: 27145936.
High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS)
Ay C, Simanek R, Vormittag R, Dunkler D, Alguel G, Koder S, Kornek G, Marosi C, Wagner O, Zielinski C, Pabinger I. High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS). Blood. 2008 Oct 1;112(7):2703-8. doi: 10.1182/blood-2008-02-142422. Epub 2008 Jun 6. PMID: 18539899.
Histological features of intracranial thrombi in stroke patients with cancer (Abstract)
Park H, Kim J, Ha J, Hwang IG, Song TJ, Yoo J, Ahn SH, Kim K, Kim BM, Kim DJ, Kim YD, Nam HS, Kwon I, Choi HJ, Sohn SI, Lee HS, Heo JH. Histological features of intracranial thrombi in stroke patients with cancer. Ann Neurol. 2019 Jul;86(1):143-149. doi: 10.1002/ana.25495. Epub 2019 May 7. PMID: 31025392.
Hypercoagulability and Mortality of Patients with Stroke and Active Cancer: The OASIS-CANCER Study
Lee MJ, Chung JW, Ahn MJ, Kim S, Seok JM, Jang HM, Kim GM, Chung CS, Lee KH, Bang OY. Hypercoagulability and Mortality of Patients with Stroke and Active Cancer: The OASIS-CANCER Study. J Stroke. 2017 Jan;19(1):77-87. doi: 10.5853/jos.2016.00570. Epub 2016 Dec 12. PMID: 28030894; PMCID: PMC5307941.
Ischemic Stroke with Comorbid Cancer Has Specific miRNA-mRNA Networks in Blood That Vary by Ischemic Stroke Mechanism
Knepp B, Navi BB, Rodriguez F, DeAngelis LM, Elkind MSV, Iadecola C, Sherman CP, Tagawa ST, Saxena A, Ocean AJ, Hull H, Jickling G, Sharp FR, Ander BP, Stamova B. Ischemic Stroke with Comorbid Cancer Has Specific miRNA-mRNA Networks in Blood That Vary by Ischemic Stroke Mechanism. Ann Neurol. 2024 Sep;96(3):565-581. doi: 10.1002/ana.26997. Epub 2024 Jun 14. PMID: 38874304; PMCID: PMC11849972.
Plasminogen activator inhibitor 1 and venous thrombosis in pancreatic cancer
Hisada Y, Garratt KB, Maqsood A, Grover SP, Kawano T, Cooley BC, Erlich J, Moik F, Flick MJ, Pabinger I, Mackman N, Ay C. Plasminogen activator inhibitor 1 and venous thrombosis in pancreatic cancer. Blood Adv. 2021 Jan 26;5(2):487-495. doi: 10.1182/bloodadvances.2020003149. PMID: 33496742; PMCID: PMC7839372.
Poor short-term outcome in patients with ischaemic stroke and active cancer (Abstract)
Kneihsl M, Enzinger C, Wünsch G, Khalil M, Culea V, Urbanic-Purkart T, Payer F, Niederkorn K, Fazekas F, Gattringer T. Poor short-term outcome in patients with ischaemic stroke and active cancer. J Neurol. 2016 Jan;263(1):150-6. doi: 10.1007/s00415-015-7954-6. Epub 2015 Nov 3. PMID: 26530513.
Rivaroxaban versus aspirin for secondary prevention of ischaemic stroke in patients with cancer: a subgroup analysis of the NAVIGATE ESUS randomized trial
Martinez-Majander N, Ntaios G, Liu YY, Ylikotila P, Joensuu H, Saarinen J, Perera KS, Marti-Fabregas J, Chamorro A, Rudilosso S, Prats-Sanchez L, Berkowitz SD, Mundl H, Themeles E, Tiainen M, Demchuk A, Kasner SE, Hart RG, Tatlisumak T; NAVIGATE ESUS investigators. Rivaroxaban versus aspirin for secondary prevention of ischaemic stroke in patients with cancer: a subgroup analysis of the NAVIGATE ESUS randomized trial. Eur J Neurol. 2020 May;27(5):841-848. doi: 10.1111/ene.14172. Epub 2020 Mar 11. PMID: 32056346.
Structure and function of thrombomodulin: a natural anticoagulant
Dittman WA, Majerus PW. Structure and function of thrombomodulin: a natural anticoagulant. Blood. 1990 Jan 15;75(2):329-36. PMID: 2153035.
Three-stage chromogenic assay for the analysis of activation properties of factor X by cancer procoagulant (Abstract)
Mielicki WP, Gordon SG. Three-stage chromogenic assay for the analysis of activation properties of factor X by cancer procoagulant. Blood Coagul Fibrinolysis. 1993 Jun;4(3):441-6. doi: 10.1097/00001721-199306000-00008. PMID: 8329571.
Thrombectomy in Patients With Active Malignancy
Siegler, James E., and Thanh N. Nguyen. "Thrombectomy in patients with active malignancy." Stroke: Vascular and Interventional Neurology 3.3 (2023): e000835.
Trends in age and sex-specific prevalence of cancer and cancer subtypes in acute ischemic stroke from 2007-2019 (Abstract)
Otite FO, Somani S, Aneni E, Akano E, Patel SD, Anikpezie N, Lamikanra O, Masoud H, Latorre JG, Chaturvedi S, Mehndiratta P. Trends in age and sex-specific prevalence of cancer and cancer subtypes in acute ischemic stroke from 2007-2019. J Stroke Cerebrovasc Dis. 2022 Dec;31(12):106818. doi: 10.1016/j.jstrokecerebrovasdis.2022.106818. Epub 2022 Oct 29. PMID: 36323171.
Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti PC, Pan YC, Olander JV, Connolly DT, Stern D. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med. 1990 Dec 1;172(6):1535-45. doi: 10.1084/jem.172.6.1535. PMID: 2258694; PMCID: PMC2188755.
[Cerebrovascular disease in the cancer patient] (Spanish)
Arboix A. Enfermedad cerebrovascular en el paciente con cáncer [Cerebrovascular disease in the cancer patient]. Rev Neurol. 2000 Dec 16-31;31(12):1250-2. Spanish. PMID: 11205569.