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ROBOS '25, The 7th Raab Outer Banks Oncology Symposium: Late Morning Sessions, July 12

July 11-12, 2025

Conference Brochure

                                                                                                                          

Role of Endoscopy in the Diagnosis and Management of Cholangiocarcinoma

Items 1-12 of 12 (Display the 12 citations in PubMed)

1.

Establishment of a prognostic nomogram and risk stratification system for patients with combined hepatocellular-cholangiocarcinoma.

Heng Q, Hou M, Leng Y, Yu H.

Sci Rep. 2025 May 14;15(1):16726. doi: 10.1038/s41598-025-01817-2.

PMID: 40369041 Free PMC article.

2.

Conversion treatment for advanced intrahepatic cholangiocarcinoma: Opportunities and challenges.

Liu JJ, Zhou M, Yuan T, Huang ZY, Zhang ZY.

World J Gastroenterol. 2025 Apr 21;31(15):104901. doi: 10.3748/wjg.v31.i15.104901.

PMID: 40309227 Free PMC article. Review.

3.

Identification of serum metabolite biomarkers and metabolic reprogramming mechanisms to predict recurrence in cholangiocarcinoma.

Prajumwongs P, Titapun A, Thanasukarn V, Jareanrat A, Khuntikeo N, Namwat N, Klanrit P, Wangwiwatsin A, Chindaprasirt J, Koonmee S, Sa-Ngiamwibool P, Muangritdech N, Roytrakul S, Loilome W.

Sci Rep. 2025 Apr 14;15(1):12782. doi: 10.1038/s41598-025-97641-9.

PMID: 40229491 Free PMC article.

4.

Cholangiocarcinoma: The era of liquid biopsy.

Kotsifa E, Saffioti F, Mavroeidis VK.

World J Gastroenterol. 2025 Mar 21;31(11):104170. doi: 10.3748/wjg.v31.i11.104170.

PMID: 40124277 Free PMC article. Review.

5.

Adjuvant treatment with Capecitabine in patients who received orthotopic liver transplantation with incidental diagnosis of intrahepatic cholangiocarcinoma. Implications on DPYD polymorphisms assessment: report of two cases and review of the literature.

Liguori C, Magi S, Mandolesi A, Agostini A, Svegliati-Baroni G, Benedetti Cacciaguerra A, Parisi A, Tiberi E, Vivarelli M, Giovagnoni A, Goteri G, Castaldo P, Berardi R, Giampieri R.

Cancer Chemother Pharmacol. 2025 Mar 12;95(1):40. doi: 10.1007/s00280-025-04756-x.

PMID: 40072607 Free PMC article. Review.

6.

IDHIRA: a prospective, observational study on ivosidenib in patients with IDH1 R132-mutated advanced cholangiocarcinoma.

Michl M, Hagemeyer N, Looß M, Grebhardt S, Ringwald K, Potthoff K.

Future Oncol. 2025 Apr;21(9):1057-1064. doi: 10.1080/14796694.2025.2470609. Epub 2025 Mar 3.

PMID: 40028796 Free PMC article.

7.

CDK4/6 inhibitors upregulate cIAP1/2, and Smac mimetic LCL161 enhances their antitumor effects in cholangiocarcinoma cells.

Menapree P, Duangthim N, Sae-Fung A, Sonkaew S, Jitkaew S.

Sci Rep. 2025 Feb 25;15(1):6826. doi: 10.1038/s41598-025-90997-y.

PMID: 40000765 Free PMC article.

8.

High preoperative Glasgow prognostic score increases a risk of hospital mortality in elderly patients with perihilar cholangiocarcinoma.

Kokumai T, Aoki S, Nakagawa K, Iseki M, Sato H, Miura T, Maeda S, Ishida M, Mizuma M, Unno M.

J Hepatobiliary Pancreat Sci. 2025 Apr;32(4):298-310. doi: 10.1002/jhbp.12111. Epub 2025 Feb 13.

PMID: 39949043 Free PMC article.

9.

Diagnostic cholangioscopy for surgical planning of extrahepatic cholangiocarcinoma.

Sung MJ, Shin SP, Kwon CI, Kang I, Lee SH, Yang SJ, Kang B, Chon HJ, Kim G, An C, Ko KH.

Sci Rep. 2025 Jan 29;15(1):3654. doi: 10.1038/s41598-024-82205-0.

PMID: 39880870 Free PMC article.

10.

Sonographic Predictors for Developing Cholangiocarcinoma: A Cohort Study from an Endemic Area.

Thanakijsombat N, Soonklang K, Hiranrat P, Limpisook P, Siripongsakun S.

Asian Pac J Cancer Prev. 2024 Dec 1;25(12):4229-4236. doi: 10.31557/APJCP.2024.25.12.4229.

PMID: 39733414 Free PMC article.

11.

Two case reports of breast cancer combined with synchronous primary intrahepatic cholangiocarcinoma/mixed liver cancer.

Tan M, Luo L, Wang T, Zhang Z, Wei Y, Long C.

Medicine (Baltimore). 2024 Nov 29;103(48):e40653. doi: 10.1097/MD.0000000000040653.

PMID: 39612433 Free PMC article.

12.

Lymph node metastasis of intrahepatic cholangiocarcinoma: the present and prospect of detection and dissection.

Zhang R, Tan Y, Liu M, Wang L.

Eur J Gastroenterol Hepatol. 2024 Dec 1;36(12):1359-1369. doi: 10.1097/MEG.0000000000002856. Epub 2024 Oct 30.

PMID: 39475782 Free PMC article. Review.

Keynote III: Patient Perspective

This list summarizes the patient perspective on cancer treatment, focusing on interactions with oncology doctors and nurses:

Patient Perspective on Cancer Treatment: Oncology Doctors and Nurses

  • Communication is Key:
    • Clarity and Honesty: Patients value clear, honest, and easy-to-understand explanations of their diagnosis, treatment options, potential side effects, and prognosis. Medical jargon should be avoided or thoroughly explained.
    • Active Listening: Feeling heard and understood by their medical team is crucial. Patients want their concerns, fears, and questions to be taken seriously and addressed empathetically.
    • Open Dialogue about Quality of Life: Discussions should include not just extending life, but also maintaining or improving quality of life during and after treatment.
    • Consistent Messaging: Patients appreciate when doctors and nurses provide consistent information, avoiding conflicting advice.
  • Empathy and Compassion:
    • Humanity: Patients want to be treated as individuals, not just a diagnosis. A compassionate and understanding approach from both doctors and nurses can significantly reduce anxiety and stress.
    • Emotional Support: Recognizing and addressing the emotional toll of cancer is vital. This includes acknowledging fear, sadness, and anger, and offering resources for psychological support.
    • Sensitivity to Pain and Discomfort: Prompt and effective management of pain and other physical symptoms is highly valued.
  • Trust and Confidence:
    • Competence and Expertise: Patients need to feel confident in their medical team's knowledge and skill.
    • Shared Decision-Making: Feeling involved in treatment decisions, with their preferences and values considered, builds trust and empowers patients.
    • Availability and Responsiveness: Knowing they can reach their medical team with urgent concerns and receive timely responses provides reassurance.
  • Nurses' Critical Role:
    • Frontline Support: Nurses are often the primary point of contact for patients, providing day-to-day care, answering questions, and offering practical advice.
    • Education and Guidance: Patients rely on nurses for detailed instructions on medication administration, side effect management, and self-care.
    • Emotional and Practical Comfort: Nurses often provide significant emotional support and practical comfort, helping patients navigate the physical and emotional challenges of treatment.
    • Advocacy: Patients appreciate nurses who advocate on their behalf to doctors regarding their symptoms, concerns, or needs.
  • Doctors' Specific Contributions:
    • Strategic Guidance: Doctors provide the overall treatment strategy, explaining the rationale behind choices and managing complex medical issues.
    • Hope and Realism: Balancing realistic expectations with appropriate levels of hope is a delicate but crucial role for oncologists.
    • Coordination of Care: Patients appreciate doctors who effectively coordinate care with other specialists and services.
  • Challenges and Frustrations:
    • Feeling Rushed: Patients can feel dismissed if appointments are too short or if they feel their questions aren't fully answered.
    • Lack of Coordination: Poor communication between different members of the care team can lead to frustration and confusion.
    • Difficulty Accessing Information: Problems with accessing medical records, test results, or understanding billing can be a significant source of stress.
    • Perceived Lack of Empathy: When patients feel their emotional distress is not acknowledged or validated.

Source: Google Gemini

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